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In hospitalized veterans with COVID-19, obstructive sleep apnea (OSA) was associated with greater use of non-invasive ventilation (NIV), but booster vaccination reduced this risk, a retrospective study found.

While univariate analysis found higher odds of low- and high-flow oxygen use, NIV, and mechanical ventilation for COVID patients with OSA, only the link with NIV remained significant after adjustment for a host of potential confounders (OR 1.83, 95% CI 1.11-3.03), reported Bharati Prasad, MD, MS, of the University of Illinois at Chicago, and coauthors.

As expected, use of pharmacological treatment for COVID-19 was associated with higher use of both high- and low-flow oxygen and NIV.

"This study adds to the current evidence and demonstrates that COVID-19 vaccine booster doses protect against acute respiratory failure progression with lower requirements for NIV and mechanical ventilation in an older, diverse population with OSA and other comorbidities," wrote Prasad and co-authors. Head over to MedPage Today to read more about it.