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Preexisting obstructive sleep apnea (OSA) was associated with up to a 75% increased risk of long COVID in adults, an analysis from the NIH RECOVER collaboration found.

Unadjusted odds of post-acute sequelae of SARS-CoV-2 (PASC) were significantly higher for adult and pediatric patients with a prepandemic OSA diagnosis, according to electronic health record (EHR) data from three research networks.

But following adjustments for factors including hospitalization, obesity, and comorbidities such as diabetes and hypertension, the association between previous OSA and PASC was reduced by various degrees and only remained significant in adults.

Women with OSA in the N3C study had an 89% increased odds of long COVID, as compared with a 59% increased odds for men with OSA (P<0.001), according to the researchers led by Hannah Mandel, MS, a senior data scientist of the New York University Grossman School of Medicine in New York City.

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